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obably¡¡is¡¡due¡¡to¡¡the¡¡fact¡¡that¡¡the¡¡flexors¡¡are¡¡stronger¡¡than¡¡the¡¡extensors¡£¡¡As¡¡muscular¡¡action¡¡is¡¡always¡¡accompanied¡¡by¡¡heat¡¡production£»¡¡the¡¡purpose¡¡of¡¡the¡¡muscular¡¡contraction¡¡and¡¡the¡¡shivering¡¡is¡¡quite¡¡certainly¡¡caused¡¡by¡¡cold¡¡to¡¡assist¡¡in¡¡the¡¡maintenance¡¡of¡¡the¡¡normal¡¡body¡¡temperature¡£

We¡¡have¡¡now¡¡discussed¡¡many¡¡of¡¡the¡¡causes¡¡of¡¡pain¡¡and¡¡in¡¡each¡¡instance¡¡we¡¡have¡¡found¡¡an¡¡associated¡¡muscular¡¡action¡¡which¡¡apparently¡¡serves¡¡some¡¡adaptive¡¡purpose¡¡£¨Figs¡£¡¡24¡¡and¡¡25£©¡£¡¡If¡¡we¡¡assume¡¡that¡¡pain¡¡exists¡¡for¡¡the¡¡purpose¡¡of¡¡stimulating¡¡muscular¡¡reactions£»¡¡we¡¡may¡¡well¡¡inquire¡¡what¡¡part¡¡of¡¡the¡¡nervous¡¡are¡¡is¡¡the¡¡site¡¡of¡¡the¡¡sensation¡¡of¡¡painthe¡¡nerve¡­endings£»¡¡the¡¡trunk£»¡¡or¡¡the¡¡brain£¿¡¡Does¡¡pain¡¡result¡¡from¡¡physical¡¡contact¡¡with¡¡the¡¡nerve¡­endings£»¡¡with¡¡the¡¡physical¡¡act¡¡of¡¡transmitting¡¡an¡¡impression¡¡along¡¡the¡¡nerve¡¡trunk£»¡¡or¡¡with¡¡the¡¡process¡¡within¡¡the¡¡brain¡­cells¡¡by¡¡which¡¡energy¡¡is¡¡released¡¡to¡¡cause¡¡a¡¡motor¡¡act£¿

It¡¡seems¡¡most¡¡probable¡¡that¡¡the¡¡site¡¡of¡¡the¡¡pain¡¡is¡¡in¡¡the¡¡brain¡­cells¡£¡¡If¡¡this¡¡be¡¡so£»¡¡then¡¡what¡¡is¡¡the¡¡physical¡¡process¡¡by¡¡which¡¡the¡¡phenomena¡¡of¡¡pain¡¡are¡¡produced£¿¡¡¡¡The¡¡one¡¡hypothesis¡¡that¡¡can¡¡be¡¡tested¡¡experimentally¡¡is¡¡that¡¡pain¡¡is¡¡a¡¡phenomenon¡¡resulting¡¡from¡¡the¡¡rapid¡¡discharge¡¡of¡¡energy¡¡in¡¡the¡¡brain¡­cells¡£¡¡If¡¡this¡¡be¡¡true£»¡¡then¡¡if¡¡every¡¡pain¡¡receptor¡¡of¡¡the¡¡body¡¡were¡¡equally¡¡stimulated¡¡in¡¡such¡¡a¡¡manner¡¡that


£ûillust¡£¡¡caption¡¡=¡¡FIG¡£¡¡¡¡25¡£FEAR¡¡AND¡¡AGONY¡£¡¡¡¡¡¨Amid¡¡this¡¡dread¡¡exuberance¡¡of¡¡woe¡¡ran¡¡naked¡¡spirits¡¡wing'd¡¡with¡¡horrid¡¡fear¡£¡¨¡¡Dante's¡¡¡¨Inferno£»¡¨¡¡Canto¡¡XXIV£»¡¡lines¡¡89£»¡¡90¡£¡¡¡¡all¡¡the¡¡stimuli¡¡reached¡¡the¡¡brain¡­cells¡¡simultaneously£»¡¡the¡¡cells¡¡would¡¡find¡¡themselves¡¡in¡¡equilibrium¡¡and¡¡no¡¡motor¡¡act¡¡would¡¡be¡¡performed¡£¡¡But¡¡if¡¡all¡¡the¡¡pain¡¡receptors¡¡of¡¡the¡¡body¡¡but¡¡one¡¡were¡¡equally¡¡stimulated£»¡¡and¡¡this¡¡one¡¡stimu¡­lated¡¡harder¡¡than¡¡the¡¡rest£»¡¡then¡¡the¡¡latter¡¡would¡¡gain¡¡possession¡¡of¡¡the¡¡final¡¡common¡¡path£»¡¡the¡¡sensation¡¡of¡¡pain¡¡would¡¡be¡¡felt£»¡¡and¡¡a¡¡muscular¡¡contraction¡¡would¡¡result¡£¡¡It¡¡is¡¡well¡¡known¡¡that¡¡when¡¡a¡¡greater¡¡pain¡¡is¡¡thrown¡¡into¡¡competition¡¡with¡¡a¡¡lesser¡¡one£»¡¡the¡¡lesser¡¡is¡¡completely¡¡submerged¡£¡¡In¡¡this¡¡manner¡¡the¡¡school¡­boy¡¡initiates¡¡the¡¡novice¡¡into¡¡the¡¡mystery¡¡of¡¡the¡¡painless¡¡plucking¡¡of¡¡hair¡£¡¡¡¡The¡¡simultaneous£»¡¡but¡¡severe¡¡application¡¡of¡¡the¡¡boot¡¡to¡¡the¡¡blindfolded¡¡victim¡¡takes¡¡complete¡¡and¡¡exclusive¡¡possession¡¡of¡¡the¡¡final¡¡common¡¡path¡¡and¡¡the¡¡hair¡¡is¡¡painlessly¡¡plucked¡¡through¡¡the¡¡triumph¡¡of¡¡the¡¡boot¡¡stimulus¡¡over¡¡the¡¡hair¡¡stimulus¡¡in¡¡the¡¡struggle¡¡for¡¡the¡¡possession¡¡of¡¡the¡¡final¡¡common¡¡path¡£¡¡¡¡Another¡¡argument¡¡in¡¡favor¡¡of¡¡this¡¡hypothesis¡¡that¡¡pain¡¡is¡¡an¡¡accompaniment¡¡of¡¡the¡¡release¡¡of¡¡energy¡¡in¡¡the¡¡brain¡­¡¡cells¡¡is¡¡found¡¡in¡¡the¡¡fact¡¡that¡¡painless¡¡stimuli¡¡received¡¡through¡¡the¡¡special¡¡senses¡¡may¡¡completely¡¡submerge¡¡the¡¡painful¡¡stimuli¡¡of¡¡physical¡¡injury£»¡¡for¡¡although¡¡the¡¡stimuli¡¡to¡¡motor¡¡action£»¡¡which¡¡are¡¡received¡¡through¡¡the¡¡senses¡¡of¡¡sight£»¡¡hearing£»¡¡and¡¡smell£»¡¡cause¡¡even¡¡more¡¡powerful¡¡motor¡¡action¡¡than¡¡those¡¡caused¡¡by¡¡physical¡¡contact¡¡stimuli£»¡¡yet¡¡they¡¡are¡¡not¡¡accompanied¡¡by¡¡pain¡£¡¡Examples¡¡of¡¡this¡¡triumph¡¡of¡¡stimulation¡¡of¡¡the¡¡special¡¡senses¡¡over¡¡contact¡¡stimulation¡¡are¡¡frequently¡¡seen¡¡in¡¡persons¡¡obsessed¡¡by¡¡anger¡¡or¡¡fear£»¡¡and¡¡to¡¡a¡¡less¡¡degree¡¡in¡¡those¡¡obsessed¡¡by¡¡sexual¡¡emotion¡£¡¡In¡¡the¡¡fury¡¡of¡¡battle¡¡the¡¡soldier¡¡may¡¡not¡¡perceive¡¡his¡¡wound¡¡until¡¡the¡¡emotional¡¡excitation¡¡is¡¡wearing¡¡away£»¡¡when¡¡the¡¡sensation¡¡of¡¡warm¡¡blood¡¡on¡¡the¡¡skin¡¡may¡¡first¡¡attract¡¡his¡¡attention¡£¡¡Religious¡¡fanatics¡¡are¡¡said¡¡to¡¡feel¡¡no¡¡pain¡¡when¡¡they¡¡subject¡¡themselves¡¡to¡¡self¡­injury¡£¡¡Now£»¡¡since¡¡both¡¡psychic¡¡and¡¡mechanical¡¡stimuli¡¡cause¡¡motor¡¡action¡¡by¡¡the¡¡excitation¡¡ofprecisely¡¡the¡¡same¡¡mechanism¡¡in¡¡the¡¡brain£»¡¡and¡¡since¡¡the¡¡more¡¡rapid¡¡release¡¡of¡¡energy¡¡from¡¡psychic¡¡stimuli¡¡submerges¡¡the¡¡physical¡¡stimuli¡¡and¡¡prevents¡¡pain£»¡¡it¡¡would¡¡seem¡¡that¡¡pain¡¡must¡¡be¡¡a¡¡phenomenon¡¡which¡¡is¡¡associated¡¡with¡¡the¡¡process¡¡of¡¡releasing¡¡energy¡¡by¡¡the¡¡brain¡­cells¡£¡¡Were¡¡physical¡¡injury¡¡inflicted¡¡in¡¡a¡¡quiescent¡¡state¡¡equal¡¡to¡¡that¡¡inflicted¡¡in¡¡the¡¡emotional¡¡state£»¡¡great¡¡pain¡¡and¡¡intense¡¡muscular¡¡action¡¡would¡¡be¡¡experienced¡£¡¡Now¡¡the¡¡emotions¡¡are¡¡as¡¡purely¡¡motor¡¡excitants¡¡as¡¡is¡¡pain¡£¡¡The¡¡dynamic¡¡result¡¡is¡¡the¡¡same¡¡the¡¡principal¡¡difference¡¡being¡¡the¡¡greater¡¡suddenness¡¡and¡¡the¡¡absolute¡¡specificity¡¡of¡¡the¡¡pain¡¡stimuli¡¡as¡¡compared¡¡with¡¡the¡¡more¡¡complex¡¡and¡¡less¡¡peremptory¡¡stimuli¡¡of¡¡the¡¡emotions¡£¡¡A¡¡further¡¡evidence¡¡that¡¡pain¡¡is¡¡a¡¡product¡¡of¡¡the¡¡release¡¡of¡¡brain¡­cell¡¡energy¡¡is¡¡the¡¡probability¡¡that¡¡if¡¡one¡¡could¡¡pierce¡¡the¡¡skin¡¡at¡¡many¡¡points¡¡on¡¡a¡¡limb¡¡in¡¡such¡¡a¡¡manner¡¡that¡¡antagonistic¡¡points¡¡only¡¡were¡¡equally¡¡and¡¡simultaneously¡¡stimulated£»¡¡then¡¡an¡¡equilibrium¡¡in¡¡the¡¡governing¡¡brain¡­¡¡cells¡¡would¡¡be¡¡established¡¡and¡¡neither¡¡pain¡¡nor¡¡motion¡¡would¡¡follow¡£¡¡¡¡An¡¡absolute¡¡test¡¡of¡¡this¡¡assumption¡¡cannot¡¡be¡¡made¡¡but¡¡it¡¡is¡¡supported¡¡by¡¡the¡¡obtainable¡¡evidence¡£¡¡We¡¡will¡¡now¡¡turn¡¡to¡¡a¡¡new¡¡viewpoint£»¡¡a¡¡practical¡¡as¡¡well¡¡as¡¡a¡¡fascinating¡¡one£»¡¡which¡¡can¡¡best¡¡be¡¡illustrated¡¡by¡¡two¡¡case¡¡histories£º¡¡A¡¡man£»¡¡seventy¡­eight¡¡years¡¡old£»¡¡whose¡¡chief¡¡complaint¡¡was¡¡obstinate¡¡constipation£»¡¡was¡¡admitted¡¡to¡¡the¡¡medical¡¡ward¡¡of¡¡the¡¡Lakeside¡¡Hospital¡¡several¡¡years¡¡ago¡£¡¡¡¡The¡¡abdomen¡¡was¡¡but¡¡slightly¡¡distended£»¡¡there¡¡was¡¡no¡¡fever£»¡¡no¡¡increased¡¡leukocytosis£»¡¡no¡¡muscular¡¡rigidity£»¡¡and¡¡but¡¡slight¡¡general¡¡tenderness¡£¡¡¡¡He¡¡claimed¡¡to¡¡have¡¡lost¡¡in¡¡weight¡¡and¡¡strength¡¡during¡¡the¡¡several¡¡months¡¡previous¡¡to¡¡his¡¡admission¡£¡¡A¡¡tentative¡¡diagnosis¡¡of¡¡malignant¡¡tumor¡¡of¡¡the¡¡large¡¡intestine¡¡was¡¡made£»¡¡but¡¡free¡¡movements¡¡weresecured¡¡rather¡¡easily£»¡¡and¡¡we¡¡abandoned¡¡the¡¡idea¡¡of¡¡an¡¡exploratory¡¡operation¡£¡¡¡¡The¡¡patient¡¡gradually¡¡failed¡¡and¡¡died¡¡without¡¡a¡¡definite¡¡diagnosis¡¡having¡¡been¡¡made¡¡by¡¡either¡¡the¡¡medical¡¡or¡¡the¡¡surgical¡¡service¡£¡¡¡¡At¡¡autopsy¡¡there¡¡was¡¡found¡¡a¡¡wide¡­spread¡¡peritonitis¡¡arising¡¡from¡¡a¡¡perforated¡¡appendix¡£¡¡A¡¡child£»¡¡several¡¡years¡¡old£»¡¡was¡¡taken¡¡ill¡¡with¡¡some¡¡indefinite¡¡disease¡£¡¡A¡¡number¡¡of¡¡the¡¡ablest¡¡medical¡¡and¡¡surgical¡¡consultants¡¡of¡¡a¡¡leading¡¡medical¡¡center¡¡thoroughly¡¡and¡¡repeatedly¡¡investigated¡¡the¡¡case¡£¡¡Although¡¡they¡¡could¡¡make¡¡no¡¡definite¡¡diagnosis¡¡they¡¡all¡¡agreed¡¡that¡¡the¡¡trouble¡¡surely¡¡could¡¡not¡¡be¡¡appendicitis¡¡because¡¡there¡¡was¡¡neither¡¡muscular¡¡rigidity¡¡nor¡¡tenderness¡£¡¡The¡¡autopsy¡¡showed¡¡a¡¡gangrenous¡¡appendix¡¡and¡¡general¡¡peritonitis¡£¡¡How¡¡can¡¡these¡¡apparently¡¡anomalous¡¡cases¡¡be¡¡explained£¿¡¡These¡¡two¡¡cases¡¡are¡¡illustrations¡¡of¡¡the¡¡same¡¡principle¡¡that¡¡underlies¡¡the¡¡freedom¡¡from¡¡pain¡¡which¡¡results¡¡from¡¡the¡¡use¡¡of¡¡narcotics¡¡and¡¡anesthetics£»¡¡the¡¡same¡¡principle¡¡that¡¡explains¡¡the¡¡fact¡¡that¡¡cholecystitis¡¡may¡¡occur¡¡in¡¡the¡¡aged¡¡without¡¡any¡¡other¡¡local¡¡symptoms¡¡than¡¡the¡¡presence¡¡of¡¡a¡¡mass¡¡and¡¡perhaps¡¡very¡¡slight¡¡tenderness£»¡¡and¡¡that¡¡accounts¡¡in¡¡general¡¡for¡¡the¡¡lack¡¡of¡¡well¡­expressed¡¡disease¡¡phenomena¡¡in¡¡senility¡¡and¡¡in¡¡infancy¡£¡¡¡¡The¡¡reason¡¡why¡¡the¡¡aged£»¡¡the¡¡very¡¡young£»¡¡and¡¡the¡¡subjects¡¡of¡¡general¡¡paresis¡¡show¡¡but¡¡few¡¡symptoms¡¡of¡¡disease¡¡is¡¡that¡¡in¡¡senility¡¡the¡¡brain¡¡is¡¡deteriorated£»¡¡while¡¡in¡¡infancy¡¡the¡¡brain¡¡is¡¡so¡¡undeveloped¡¡that¡¡the¡¡mechanism¡¡of¡¡association¡¡is¡¡inactive£»¡¡hence¡¡pain¡¡and¡¡tenderness£»¡¡which¡¡are¡¡among¡¡the¡¡oldest¡¡of¡¡the¡¡associations£»¡¡are¡¡wanting¡£¡¡Senility¡¡and¡¡infancy¡¡are¡¡by¡¡nature¡¡normally¡¡narcotized¡£¡¡The¡¡senile¡¡are¡¡passing¡¡through¡¡the¡¡twilight¡¡into¡¡the¡¡night£»¡¡while¡¡infants¡¡are¡¡traversing¡¡through¡¡the¡¡dawn¡¡into¡¡the¡¡day¡£¡¡Hence¡¡it¡¡is¡¡that¡¡the¡¡diagnosis¡¡of¡¡injury¡¡and¡¡disease¡¡in¡¡the¡¡extremes¡¡oflife¡¡is¡¡beset¡¡by¡¡especial¡¡difficulties£»¡¡since¡¡the¡¡entire¡¡body¡¡is¡¡as¡¡silent¡¡as¡¡are¡¡the¡¡brain£»¡¡the¡¡pericardium£»¡¡the¡¡mediastinum£»¡¡and¡¡other¡¡symptomless¡¡areas¡£¡¡¡¡For¡¡the¡¡same¡¡reason£»¡¡when¡¡a¡¡patient¡¡who¡¡is¡¡seriously¡¡ill¡¡with¡¡a¡¡painful¡¡disease¡¡turns¡¡upon¡¡the¡¡physician¡¡a¡¡glowing¡¡eye¡¡and¡¡an¡¡eager¡¡face£»¡¡and¡¡remarks¡¡how¡¡comfortable¡¡he¡¡feels£»¡¡then¡¡the¡¡end¡¡is¡¡near¡£¡¡¡¡This¡¡is¡¡a¡¡brilliant¡¡and¡¡fateful¡¡clinical¡¡mirage¡£¡¡When¡¡one¡¡reflects¡¡on¡¡the¡¡vast¡¡amount¡¡of¡¡evidence¡¡as¡¡to¡¡the¡¡origin¡¡and¡¡the¡¡purpose¡¡of¡¡pain£»¡¡he¡¡is¡¡forced¡¡to¡¡conclude¡¡that¡¡pain¡¡is¡¡a¡¡phenomenon¡¡of¡¡motor¡¡stimulation£»¡¡and¡¡that¡¡its¡¡principal¡¡role¡¡is¡¡the¡¡protection¡¡of¡¡the¡¡individual¡¡against¡¡the¡¡gross¡¡and¡¡the¡¡microscopic¡¡enemies¡¡in¡¡his¡¡environment¡£¡¡¡¡The¡¡benefits¡¡of¡¡pain¡¡are¡¡especially¡¡manifested¡¡in¡¡the¡¡urgent¡¡muscular¡¡actions¡¡by¡¡means¡¡of¡¡which¡¡the¡¡body¡¡moves¡¡away¡¡from¡¡physical¡¡injury£»¡¡obstructions¡¡of¡¡the¡¡hollow¡¡viscera¡¡are¡¡overcome£»¡¡rest¡¡is¡¡compelled¡¡in¡¡the¡¡acute¡¡infections¡¡the¡¡infected¡¡points¡¡are¡¡held¡¡rigidly¡¡quiet£»¡¡the¡¡muscles¡¡of¡¡the¡¡abdomen¡¡are¡¡fixed£»¡¡and¡¡harmful¡¡peristalsis¡¡is¡¡arrested¡¡in¡¡peritonitis£»¡¡while¡¡there¡¡is¡¡absolutely¡¡no¡¡pain¡¡in¡¡the¡¡diseases¡¡or¡¡injuries¡¡which¡¡affect¡¡those¡¡regions¡¡of¡¡the¡¡bo

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